the d-retro inverso dri isoform of foxo4 FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion upregulated p53-serine 15 phosphorylation The disordered p53 transactivation domain
The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4 DRI Nature Communications FOXO4 DRI Wikipedia A paper published in Cell investigated the effects of a FOXO4 peptide to target senescent cells in mice and reported improved kidney function and restoration of fur, suggesting that this could lead Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging: Cell Current perspective on the regulation of FOXO4 and its role in disease progression Cellular and Molecular Life Sciences Springer Nature Link
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