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Frohman LA, et al

however, these oral uses are limited by their side effects, such as nausea, diarrhoea, and headaches, and inhaled drugs have proven ineffective so far

Some people who undergo Botox treatment notice mild headaches for a short period of time because of how your body reacts to the treatment

These include regulation of mechanisms controlling reactive oxygen species (ROS), which cause macromolecular damage 16,17 , mitochondrial turnover or mitophagy 18 , and the mitochondrial unfolded protein response (UPR mt ), in which mitochondrial damage can be prevented by the removal of aggregated or unfolded proteins 19

Palmer BF (2002) Renal dysfunction complicating the treatment of hypertension