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5 Antioxidants are most effective in combating low levels of ROS generation, but have a limited capacity to reduce high levels

Mechanisms of immune response to inorganic nanoparticles and their degradation products

For example, it has been shown that exceeding the upper limit of selenium intake (400 g/d) can lead to selenotoxicity, but no significant symptoms of toxicity were observed when selenium was ingested in the form of SeNPs (1,600 g/d), and some selenotoxicity symptoms did not occur until even an intake of 3,200 g/d (255)

Arch Gynecol Obstet 291:12831288 Iqubal A, Iqubal MK, Sharma S, Ansari MA, Najmi AK, Ali SM, Ali J, Haque SE (2019) Molecular mechanism involved in cyclophosphamide-induced cardiotoxicity: old drug with a new vision