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Thereafter, the inflammation induces endoplasmic reticulum (ER) stress via unfolded protein response pathways, resulting in metabolic disorders and apoptosis

Int J Psychiatry Clin Pract 24(2):127134 Akhtar A, Dhaliwal J, Saroj P, Uniyal A, Bishnoi M, Sah SP (2020) Chromium picolinate attenuates cognitive deficit in ICV-STZ rat paradigm of sporadic Alzheimers-like dementia via targeting neuroinflammatory and IRS-1/PI3K/AKT/GSK-3 pathway