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Astrocytes overexpressing mSOD1 release soluble factors that trigger degeneration of motor neurons, with motor neurons overexpressing mSOD1 being particularly vulnerable

Repeat as needed every 2 to 4 hours

Imaging in patients with manganese-related movement disorders Due to the paramagnetic properties of Mn, its deposition in the pallidum is detected as hyperintensities in the globus pallidus on magnetic resonance imaging (MRI) and is a characteristic MRI finding in the brain [39]