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A recent reviews and meta-analysis provide a more homogeneous picture of the local and systemic alterations in glaucoma patients, revealed an overall increase in oxidative stress markers in chronic glaucoma, in both the serum and the AH

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MDSC produces immunosuppressive cytokines such as IL 10, TGF-, etc., increases PD-L1, and prostaglandin E2 (PGE2) expression, and recruits Tregs which collectively suppresses the T-cell (CD8 + ), maintains stemness (like in ovarian CSCs), and drug resistance[167,168,169], as shown in Fig