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Apoptosis regulatory effector: caspase-1 Caspase-1 is an effector enzyme of pyroptosis, promoting the maturation and secretion of potent pro-inflammatory cytokines such as IL-1 and IL-18 in humans and mice, as well as a form of inflammatory lytic cell death known as pyroptotic cell death. Human caspase-4 and caspase-5, along with their murine homolog caspase-11, mediate the activation of noncanonical inflammasomes

Achieving these long-term goals relies on deepening interdisciplinary collaboration, including close cooperation among basic mechanism researchers, biomaterial scientists, clinical orthopedics and rheumatology experts, and pharmacokinetics and toxicology assessment experts

Hydroxyl radicals, among the most aggressive ROS, preferentially oxidize proteins and lipids

Bioprinting 5 , 165 (2019)