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SUPPLEMENTARY FIGURE LEGENDS SUPPLEMENTARY TABLES Supplementary table 1: Metabolic pathway enrichment score in tumor environment cell types Supplementary table 2: Metabolic pathways enrichment score in cancer cells Supplementary table 3: TIF metabolite levels Supplementary table 4: Plasma metabolite levels Supplementary table 5: CRISPR screen hits Supplementary table 6: Amino acid concentrations in custom-made RPMI Supplementary table 7: Oligonucleotides for generation of GOT1/2 KOs Supplementary table 8: m/z ratios and retention times for a panel of metabolites meas-ured in TIF and plasma Supplementary table 9: Primers for CRISPR screen and PCR conditions Supplementary table 10: scRNAseq Quality metrics and parameters of analysis ACKNOWLEDGEMENTS We acknowledge the financial support from the Czech Science Foundation (24-10167S, J.R), Eu-ropean Research Council (101042031 InterMet, K.R.), MSCA (101027977 MetaCross, K.R.), EMBO (5068, K.R.), MEYS and ERDF/ESF (project CZ.02.01.01/00/22_010/0008608, J.W.S.), MSCA WIDERA (101068637 - EC-InterCom, P.H.), GAUK (1435320, M.M.), MISTI Global Seed Funds (0000000710, K.R

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