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moreover, there is substantial evidence suggesting that, among other regulatory cytokines, IL-1 participates in transduction signals in oxidative injury via ROS and has stimulatory effects on regulatory transcription factors mediating apoptosis [163170]

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However, excessive alcohol consumption disrupts this balance by generating an overabundance of ROS and other reactive molecules while impairing the bodys antioxidant defenses

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It is known to show several different modes of intracellular localization: to the cytoplasm (cGPX4), mitochondria (mGPX4), and nucleolus (nGPX4) [28]

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