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In whole blood of people with BD in the depressive phase, the expression of genes in the ETC pathway are the most significantly altered compared to healthy controls, with 22 genes upregulated and 2 downregulated in BD [49]

In contrast, larger Pt nanozymes may not be readily cleared renally and could be eliminated via alternative pathways (e.g., fecal excretion), potentially posing risks associated with metal accumulation and long-term toxicity

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Missing one or two doses does not create a clinically significant depletion state

Recent studies strongly support a role of vitamin D in prevention of atherosclerosis, probably by influencing inflammatory activity of macrophages