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These include: Pain, redness, or swelling at the injection site Bruising or hardening of tissue (induration) Itching or warmth around the injection area Temporary discolouration of the skin These localised reactions typically resolve within 2472 hours

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However, tumor cells often downregulate HLA-I and allow effector NK cells to be activated by immunoreceptor tyrosine-based activation motifs (ITAMs) in intracellular domains, resulting in the release of cytokines, perforins and granzyme B and leading to tumor cell death

Treatment is designed to help maintain adequate vitamin B12 levels under medical supervision

Direct head-to-head randomized human trials are practically non-existent, so comparisons regarding human efficacy should be interpreted carefully