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FDA (2020)

Hoque MA, Chisty NN, Guttin T, Irin N, Baillie S (2023)

Furthermore, apoptotic cells in SLE often congregate in germinal centers to avoid macrophage clearance and deliver survival signals to autoreactive B cells, which may contribute to the loss of immune tolerance (86)

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The high concentrations of pharmacological BH4 that are required to generate a biological effect in many studies suggest that biopterins do not enter cells merely by passive diffusion