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Funding statement This work was supported by the National Natural Science Foundation of China 81703483 (to W.W.)

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Beyond hemoglobin, iron also powers myoglobin (oxygen storage in muscles), cytochrome enzymes in the mitochondrial energy chain, and the oxidative burst neutrophils use to kill pathogens

Considering the recent surveys that document much improved safety of kratom compared to the prescription or illicit opioids 83,93,94 , a further decrease of MORs G protein signaling efficacy of the key mediator of kratoms opioid-like effects, 7OH 17 , may lead to even safer compounds, and illustrates the potential importance of the present work

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