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Description

The resulting calcium elevation triggers immediate GH vesicle exocytosis, while PKC modulates secretory machinery sensitivity and regulates GH pulse frequency patterns

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By binding directly to IGF-1 receptors on muscle cells, IGF-1 LR3 activates downstream anabolic pathways including PI3K/Akt and MAPK signalingpromoting protein synthesis, glucose uptake, cellular proliferation, and satellite cell activation