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Cartilage: Has no direct blood supply Relies on diffusion for nutrient delivery Contains relatively few cells (chondrocytes) Has low regenerative capacity Chondrocytes are responsible for: Producing collagen (primarily type II) Producing proteoglycans such as aggrecan Maintaining extracellular matrix structure When chondrocytes become dysfunctional due to inflammation, mechanical stress, or aging, cartilage degradation accelerates

3 = diffuse occurrence of 1116 necrotic cells/HPF (foci of confluent necrosis)

Administer B12 once a week for 4 weeks

Because these symptoms can also be linked to other health conditions, its important to seek guidance from a trusted healthcare provider

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