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Since the more mildly-affected participants often responded well to cofactor therapy alone, and that the side effects of the cofactors are generally much less than that of the medications [5 and author's experience], a trial of cofactor and dietary therapy alone may be warranted in most CVS patients encountered in clinical practice, with amitripyline or cyproheptidine added in refractory cases

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It provides energy to immune cells and may positively impact the functionality of leukocytes during the acute phase response, a situation of high energy demand

B-cell dynamics during experimental endotoxemia in humans

30 : 555559 Janiri L, Falcone M, Persico A, Tempesta E