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Also, treatment with busulfan as a cytotoxic agent can cause abnormal apoptosis in spermatogonial cell lines, leading to a pathological condition

Thus, the AR remains a potential therapeutic target for prostate cancer therapy 39

Elderly The capacity of elderly patients (age range: 68 to 89 years) to eliminate valproate has been shown to be reduced compared to younger adults (age range: 22 to 26)

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