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Notably, the depletion of anti-HMGB1 neutralizing antibody or arginine catabolism enzyme (AGRE) mitigates macrophage inflammatory responses, suggesting that restricting HMGB1 expression may be a potential approach for managing macrophage inflammation (103, 104)

GTX100332, Genetex), Collagen II (1:50

10.1016/j.jtcme.2016.05.005 16 BagherianA.MardaniR.RoudiB.TaghizadehM.BanfsheH

Assessing thiopurine metabolites such as 6-TG and 6-methylmercaptopurine (6-MMP) can be instrumental in tailoring therapy and monitoring treatment adherence in AIH