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doi: 10.1016/S1368-7646(98)80038-1 103 MenndezJ

Numerous studies have demonstrated that adherence to a MeDi, rich in diverse nutrients and phytochemicals, exerts anti-inflammatory, antioxidant, and anti-atherosclerotic effects, thereby lowering cardiovascular and cerebrovascular risk (Tuttolomondo et al., 2019)

Resistance-associated mutations in the receptor tyrosine kinase (RTK) pathway or secondary KRAS mutations have been frequently observed in patients, particularly in CRC, where up to 73% of patients exhibit acquired genomic alterations upon disease progression (NCT03600883) [165]