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Your body burns stored fat for energy more efficiently while storing less new fat from your diet

This raises questions about its safety with regards to cancer growth, especially in tissues known to form polyps or where there could be pre-existing tumor conditions 1

PloS ONE 9 , e97673 (2014)

If nausea is severe enough to prevent adequate nutrition, reduce both compounds to the last tolerated dose and extend the stabilization period before attempting re-escalation