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Long-term NSAID use can lead to gastritis and gastric ulcers

For example, inhalers are the preferred route of administration for the asthma treatment albuterol because they are faster acting at a lower dose than tablets or liquid, which are more likely to cause serious side effects like headaches or tachycardia

Antidiabetic medicines such as metformin: Long-term use may reduce vitamin B12 absorption and increase the requirement for cyanocobalamin supplementation