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10.1126/science.1144640 154 PereaG.GomezR.MederosS.CoveloA.BallesterosJ

The formation and progression of cysts in ADPKD are also associated with oxidative stress, inflammation, and cell death (268, 269)

The most prominent of these is spectrin, a filamentous protein that forms a supportive lattice beneath the membrane, critical for the biconcave disk shape and for providing the flexibility needed to traverse narrow capillaries (9)