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Females of childbearing potential must use two reliable forms of contraception simultaneously during oral tretinoin therapy and for one month following discontinuation of therapy, unless abstinence is the chosen method

Philpott et al

Studies have shown that obesity and a high-fat diet can lead to impaired reproductive ability, affecting the molecular sperm structure, fetal development, and offspring health (Figure 3

Thus, this stabilization approach offers the potential for developing formulations suitable for further pharmacological and clinical studies (68)

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