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Epitalon consists of only four amino acids (Ala-Glu-Asp-Gly), making it one of the shortest peptide compounds utilized in peptide pharmacology research

12,13 In addition, high blood pressure, chronic oxidative stress (another way of saying high levels of free radicals), and chronic low-grade inflammation are also risk factors

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Additionally, existing cryo-EM structures all locate the catalytically active strand break at the same location relative to the rest of the complex, at the top, opposite the XLF/XRCC4/Ku protein interaction framework that bridges the two ends (Fig