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Brainstem serotonin and norepinephrine producing nuclei (dorsal raphe nucleus and locus coeruleus, respectively) are vulnerable to cell loss, tau deposition and -synuclein pathology early in normal aging, AD and PD [59, 60, 61] This early involvement of brainstem nuclei is thought to contribute to the high prevalence of depression, anxiety, and sleep disturbance, preceding cognitive decline and motor symptom onset [61,62,63,64,65]

Kanehisa M, Furumichi M, Sato Y, Kawashima M, Ishiguro-Watanabe M (2023) KEGG for taxonomy-based analysis of pathways and genomes

Predictive value of free triiodothyronine (FT3) to free thyroxine (FT4) ratio in long-term outcomes of euthyroid patients with three-vessel coronary artery disease. Nutrition, metabolism, and cardiovascular diseases : NMCD vol

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When levels are low, cells are left more vulnerable to oxidative damage accelerating the aging process and increasing the risk of various chronic diseases