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Hepatology 76 , 1831 (2022)

[34] Cua DJ, Tato CM

This study first demonstrated that TSA suppresses AF through dual modulation of prolonged post-repolarization refractoriness and conduction slowing, offering a novel therapeutic strategy for AF in patients with CHF

With a molecular weight of just 403.93 Da well below the 500 Da cutoff typically associated with significant skin penetration GHK-Cu is small enough to penetrate the stratum corneum (outer skin layer) in concentrations sufficient to activate regenerative processes

However, the altered flux of amino acids and their metabolites through transporters, cytosolic pools, MTS and competing pathways when using methionine as the sole source of reducing power might still be more taxing to the cells