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A comprehensive 2026 review examining peptide and peptide-analogue use across sport and bodybuilding contexts (PMID 41880199) identified ipamorelin as one of the most widely circulating GHRPs in non-clinical settings, noting that its pharmacological profile including reduced risk of ACTH-mediated adverse effects relative to older GHRPs has contributed to its prominence in both research and off-label demographics

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This effect was shown in a study published in the Journal of Clinical Investigation

The people who maintain the most lean mass during GLP-1-assisted weight loss are consistently the ones who combine their medication with structured exercise