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The intention of taking a PPI is to reduce the activity of gastric proton pumps, thus lowering gastric acid production and alleviating reflux, peptic ulcers, and indigestion

Although we have demonstrated target engagement of both compounds, additional experiments could also explore the possibility of off-target effects of both SIH and Lip-1

Transcellular water movements are facilitated by the water channels, aquaporins (AQP) type 9 and 8, located at the basolateral and apical membranes, respectively.46 As expected for a solute exerting osmotic forces at the canalicular level, a linear relationship between bile salt secretion and bile flow has been observed in all vertebrates, including man

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