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The gut-joint axis: microbial dysbiosis and OA Emerging evidence firmly establishes a link between gut microbiota dysbiosis and OA progression, primarily mediated by microbial metabolites via the gut-joint axis. The core protective mechanism involves short-chain fatty acids (SCFAs) like butyrate and propionate, produced from dietary fiber fermentation by commensals such as Bacteroides and Faecalibacterium prausnitzii