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A pharmacokinetic study showed that plasma samples assayed from healthy volunteers given 200 mg (multiple intakes over 5 days) and 300 mg (single-dose intake) of PYC, tested 4 h after the last intake and 14 h after the single-dose intake, revealed that catechins, paclitaxel, caffeic acid and ferulic acid, as well as the intestinal microbial the metabolite 5-(3,4-dihydroxyphenyl)--valerolactone content was significantly increased (Grimm et al., 2006)

The stock solutions were diluted in VPM to the respective working concentrations without exceeding a DMSO concentration of 0.1% to rule out unspecific solvent toxicity

doi: 10.1210/jcem.87.1.8129 80 SeidelMMarkmann JensenSHealyDDurejaAWatsonHJHolstBet al

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Generating robust clinical evidence for HIF-1 inhibition is further complicated by these challenges