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Peer review Peer review information Nature Communications thanks Rudolf Oehler, Robert Hoffman and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

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Lower CNS [GSH] and [NAA] 30 min after naloxone were associated with worse behavioral scores and greater symptoms of withdrawal

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By sustaining the GSH level, GR can enhance the cellular antioxidant capacity and strengthen the resilience against oxidative stress 54

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It contributes to the proper functioning of the immune system and is important for the proper functioning of the

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HIF-1 suppresses ROS generation by enhancing glycolysis, inhibiting the TCA, and promoting an upregulation in antioxidants

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