glutathione s transferase dyclonine S-transferase: A keystone in Parkinson's disease pathogenesis and therapy glutathione s transferase mechanism Glutathione

The diminished export results in hepatic lipid overload and subsequent intracellular lipid accumulation, leading to steatosis, lipotoxicity, and liver damage, and promoting disease progression and fibrosis

In addition to TNF- and IL-1, recent studies have suggested that IL-6 contributes to ferroptosis by impairing antioxidant defense and altering iron metabolism (48,49)

& Scheuermann, J

Molecules and cells, 19, 1316

Furthermore, studies have indicated that individuals with chronic liver diseases often have depleted levels of glutathione, suggesting a direct correlation between low glutathione levels and impaired liver health