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After both lisdexamfetamine and D-amphetamine administration, the subjective drug effect-concentration curves revealed similar clockwise hysteresis, indicating similar extents of acute pharmacological tolerance to lisdexamfetamine and D-amphetamine ( Supplementary Figure S3 )

[iv] Challenges Associated With FIH Trials Since these studies represent the first administration of an investigational drug in humans, they are associated with inherent challenges, especially safety

The fibers of the gluteus maximus , the largest buttock muscle, are split