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Studies using different, but complementary, gut-microbiota directed interventions (Germ Free (GF) rodents, antibiotics, probiotics, gastrointestinal (GI) infection studies, and fecal microbiota transplantation studies) have all suggested a number of possible brain-gut signaling pathways under the influence of the gut microbiota and capable of modulating brain and behavior (Rhee et al., 2009

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Indeed, in our own publications we have come down both for13 and against4 the down regulation of AR by androgens

Abstract The insulin-like growth factor 1 receptor (IGF-1R) governs several signaling pathways for cell proliferation, survival, and anti-apoptosis

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