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Frank deficiency (below 145 pmol/L), post-RYGB or post-BPD-DS: intramuscular injection, loading regimen followed by monthly maintenance

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In addition to acting on opioid receptors, opioid peptides have also been shown to interact with toll-like receptors (TLR), particularly TLR4 (Eidson and Murphy 2013

This not only makes the area appear darker but may also encourage frequent rubbing or scratching, which can increase pigmentation and worsen the shadowed look