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B12 injections are better for people with absorption issues or moderate-to-severe deficiency because they bypass the digestive system

Decreased alpha-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson's disease

So while this comparison raised questions about how the treatment stacks up against competitors, it doesnt necessarily affect its chances of approval

Importantly, this metabolic adaptation did not correlate with a diminution of mitochondrial function, indicating that acute exposure to high glucose triggers a robust and synergistic activation of both glycolytic and oxidative pathways (Esen and Long 2014)