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10.1007/s12035-016-0272-x 298 VintsW

Interestingly, introduction of carboxylic acid groups to RT slows down its reaction kinetics towards GSH comparing to RT-NH 2 and TQG-CN (Table 2), presumably due to the charge repulsion between the carboxylic acid groups and the anionic GSH

R.ShahJ.SanghaN.SosaL.MartinezR.ShenL.et al (2013)

There is also an increased risk of oral, gastric, and colon cancer associated with low dietary niacin intake, along with esophageal dysplasia

Rare but more serious risks include infection at the IV site, vein irritation (phlebitis), electrolyte imbalance (with high-dose formulations), or allergic reaction