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Zhang H, Dougherty PM

Furthermore, in a phase 2 basket trial of anti-PD-1 monotherapy with pembrolizumab, all five enrolled patients with RMC consistently showed progressive disease, with a median time to progression of only 8.7 weeks, irrespective of PD-L1 expression or tumor-infiltrating lymphocyte (TIL) levels 13

Insulin also contributes to the regulation of the pyruvate dehydrogenase complex by activating pyruvate dehydrogenase phosphatase

One of the things that makes it complicated is that it's not a stand-alone number

Furthermore, they strongly suggest that the pathogenic mechanisms underlying the hyh phenotype involve not only a reduction of mutant protein levels but also defects in -SNAP protein-lipid interaction