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Calcium homeostasis is maintained through SERCA2a activation to enhance calcium reuptake and restore normal flux, while inhibiting Ca 2+ -dependent calcineurin/calpain/CaMKII activity to prevent calcium overload-induced remodeling (Hedayati et al., 2023)

These findings are consistent with the results from our co-culture assay (Fig

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MH and SP both up-regulate glucose metabolism in the brains of ROT-induced PD mice To measure glucose metabolism in mouse brains, mice from both the NC and ROT groups (Table S8) were subjected to neuro-imaging through [18F]-fluorodeoxyglucose positron emission tomography ( 18 F-FDG PET) (Supplementary Materials)