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In addition, inhibiting GHSR1as G q using siRNA did not result in loss of dopamine-induced Ca 2+ mobilization, but did significantly reduce ghrelin-induced Ca 2+ mobilization

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This review explores existing evidence that shows that CL biology is regulated by a series of tightly integrated genetic, hormonal, metabolic, and epigenetic regulatory networks in mammalian species

Hence, therapeutic strategies aimed at enhancing glial GSH synthesis or exporting ability may help modulate glial-immune phenotypes, reduce microglial activation, and slow progressive CNS degeneration in neurodegenerative diseases (Figure 2)