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TNF- plays an important roles in many processes, such as cell survival, apoptosis, necrosis, and intercellular communication 27

Oral anaerobes generate volatile sulfur compounds (VSCs) such as hydrogen sulfide and methanethiol, which may modulate inflammatory signaling and epithelial integrity within the respiratory mucosa 195 , while organic acids and tryptophan-derived metabolites produced by oral commensals may further alter microbial colonisation patterns and host immune responses in the airways 196

Vitamin D3 protects against diabetic retinopathy by inhibitinghigh-glucose-induced activation of the ROS/TXNIP/NLRP3 inflammasome pathway

Unlike acute wounds, which follow a well-defined healing cascade of re-epithelialization, fibroblast proliferation, and angiogenesis, chronic wounds remain trapped in a prolonged inflammatory phase characterized by microbial persistence and dysregulated immune responses [4,5,6]