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Interestingly, the TME not only facilitates drug liberation, but could also be manipulated by metal nanomedicines (Zhang et al., 2020a

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[0375] In some embodiments, when a subject is treated with the compositions of the disclosure, the subject exhibits a reduction in acne compared to pre-treatment of about 5 %, or about 10 %, or about 15 %, or about 20 %, or about 25 %, or about 30 %, or about 35 %, or about 40 %, or about 45 %, or about 50 %, or about 55 %, or about 60 %, or about 65 %, or about 70 %, or about 75 %, or about 80 %, or about 85 %, or about 90 %, or about 95 %, or more

With respect to commenters urging the need for CMS to provide ACOs with detailed responses to ACO reopening requests, including for the purposes of notifying its participants of the outcome, and for the ACO to adjust ( payment or incentives participants may receive, we note that in the event we decide to reopen an ACO's payment determination and issue a revised initial determination, we anticipate specifying related information in a financial reconciliation report delivered to the ACO