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Description

The SIRT1/Nrf2/GPX4 pathway was identified as a protective mechanism, with SIRT1 knockdown reversing this effect

Lung, WAT, testis, and skeletal muscle preferentially rely on salvage and have low expression of proteins involved in the PreissHandler pathway 41 , with the muscle in particular relying on both NRK1 and NRK2 for supporting its mitochondrial metabolism and fiber type composition 42