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Despite there is a lack of studies yet, we consider that future works could be directed to study the gut microbiota in episodes with mixed features, also focusing on the study of hypomanic/manic phases in order to establish and understand differences occurred in each phase (Fig

In the head-to-head SURMOUNT-5 trial, tirzepatide produced a mean 20.2% weight loss versus 13.7% for semaglutide at 72 weeks