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Under conditions of cellular stress, injury, or mitochondrial dysfunction, mtDNA can escape into the cytoplasm, where it activates the cGAS (cyclic GMPAMP synthase)STING (stimulator of interferon genes) signaling pathway, or it can be detected extracellularly by Toll-like receptors on immune cells

3, 3-Diindolylmethane modulates estrogen metabolism in patients with thyroid proliferative disease: a pilot study

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Metformin protects against pulmonary hypertension-induced right ventricular dysfunction in an age- and sex-specific manner independent of cardiac AMPK

Acknowledgments We are grateful to Biorender (BioRender.com) for their assistance in graphic illustration