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Besides, to further confirm peroxynitrite-mediated activation of the NF-B pathway, we also measured the mRNA expression levels of known NF-B p65 target genes Bax , P53 , Bcl2 , and Bcl-xL

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PGC-1 is regarded as a key regulator of mitochondrial metabolism and is essential in controlling cardiac energy metabolism remodeling

67 , 68 , 69 By 1989, physicians/doctors reported excessive iron as a potent risk associated with cancer, at levels significantly lower than estimated safe in the past