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PER1 affects cancer growth and causes an increased rate of ionizing radiation-induced cell death, but it is unclear whether its lack of expression precedes and contributes to cancer development, or is the only source of cancer

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doi: 10.3390/GENES15070903 61 PanLLiJXuQGaoZYangMWuXet al

For instance, increased exhausted PD1+ natural killer (NK) cells have been reported in advanced stages of the disease, indicating a role for immune checkpoint dysregulation in disease progression and potential as a diagnostic target