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One of the key regulators of oxidative stress in diabetes is thioredoxin-interacting protein (TXNIP), which acts as an endogenous inhibitor of the antioxidant thioredoxin (TRX)

Owing to the pronounced heterogeneity of IBD, biologics and small-molecule agents elicit highly variable responses, with approximately 3040% of patients experiencing primary or secondary loss of response [17]

Int J Mol Sci 21:6351 Sparano JA, Lee JY, Kaplan LD, Levine AM, Ramos JC, Ambinder RF, Wachsman W, Aboulafia D, Noy A, Henry DH (2010) Rituximab plus concurrent infusional EPOCH chemotherapy is highly effective in HIV-associated B-cell non-Hodgkin lymphoma