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Conversely, DUSP4-deficient mice show an enhancement of STAT5 phosphorylation and IL-2 production in T cells, resulting in CD4 + T cell hyperproliferation [76]

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Among these, it was shown that trimethylamine-N-oxide (TMAO) positively correlated with PsA skin and peripheral joint activity 27 , and pro-inflammatory eicosanoids PGE2, HXB3 and 6,15-dk, dh, PGF1a and anti-inflammatory eicosanoids 11-HEPE, 12-HEPE and 15-HEPE correlated with joint disease score in PsA patients 28

Subsequently, selection medium was refreshed every 3 d as cells were expanded up to 10-cm plates

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