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The article will need updating if FDA issues a decision or Novo Nordisk changes its development plan

Annexin-V binding can happen in two cases: when phosphatidylserine is externalized to the outer layer of the cell membrane or when pores in the cell membrane are formed

156 Importantly, pregabalin can damage the retinal nerve and is therefore contraindicated for those with diabetic retinopathy or glaucoma

Additionally, its potential to reduce reactive oxygen species (ROS) in dermal layers makes it an attractive candidate for studying oxidative stress modulation